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- Title
MRI Study of Jellyfish Collagen, Hyaluronic Acid, and Cadaveric Dermis for Injection Laryngoplasty.
- Authors
San‐Marina, Serban; Bowen, Andrew J.; Oldenburg, Michael S.; Voss, Stephen G.; Hunter, Danielle E.; Macura, Slobodan; Meloche, Ryan; Miller, Alen Lee; Spragg, Andrew Mearns; Ekbom, Dale C.
- Abstract
Objectives/Hypothesis: Test a new jellyfish collagen biomaterial aimed to increase duration of injection medialization laryngoplasty (IL) against two products in clinical practice. Study Design: Animal model. Methods: Left recurrent laryngeal nerve sectioning and IL were performed in New Zealand White rabbits (N = 6/group). Group 1 received micronized cross‐linked jellyfish collagen (MX‐JC) and adipose derived stem cells (ADSCs), Group 2, MX‐JC alone, Group 3, cross‐linked hyaluronic acid (X‐HA), and Group 4, micronized acellular dermis (MACD). Animals were sacrificed at 4 and 12 weeks. Major outcomes were MRI tissue volumes and histopathology. Results: After 100 μL IL MRI volumes (means ± STD) at 4 and 12 weeks were: Group 1: 27.2 ± 15.6 and 13.1 ± 5.2 μL, Group 2: 60.8 ± 18 and 27.8 ± 2.47 μL, Group 3: 27.4 ± 12 and 10.6 ± 8 μL, and Group 4: 37.5 ± 11 and 9.85 ± 1 μL. Group 2 volumes were largest and Group 3 were smallest in all comparisons (P <.05). Histologically, low grade inflammatory responses were observed in Group 1, mild histiocytic infiltration in Group 2, widespread muscle fiber loss in Group 3, and plasmocytic infiltration in Group 4. Conclusions: MX‐JC showed the least resorption at 4 and 12 weeks among all groups. T cell inflammatory responses were observed with MX‐JC but were reduced by 12 weeks while B cell immune responses, indicative of antibody priming, were predominantly noted with MACD. MX‐JC + ADSC showed low grade immunity while the XHA showed greater myocyte loss compared to the other groups. Level of Evidence: NA Laryngoscope, 131:E2452–E2460, 2021
- Subjects
RECURRENT laryngeal nerve; HYALURONIC acid; INJECTIONS; LARYNGOPLASTY; JELLYFISHES
- Publication
Laryngoscope, 2021, Vol 131, Issue 8, pE2452
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1002/lary.29501