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- Title
The complex role of adipokines in obesity, inflammation, and autoimmunity.
- Authors
Taylor, Erin B.
- Abstract
The global obesity epidemic is a major contributor to chronic disease and disability in the world today. Since the discovery of leptin in 1994, a multitude of studies have characterized the pathological changes that occur within adipose tissue in the obese state. One significant change is the dysregulation of adipokine production. Adipokines are an indispensable link between metabolism and optimal immune system function; however, their dysregulation in obesity contributes to chronic low-grade inflammation and disease pathology. Herein, I will highlight current knowledge on adipokine structure and physiological function, and focus on the known roles of these factors in the modulation of the immune response. I will also discuss adipokines in rheumatic and autoimmune diseases.
- Subjects
ADIPOKINES; PATHOLOGY; PATHOLOGICAL physiology; AUTOIMMUNITY; OBESITY
- Publication
Clinical Science, 2021, Vol 135, Issue 6, p731
- ISSN
0143-5221
- Publication type
Article
- DOI
10.1042/CS20200895