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- Title
Molecular pathways in protecting the liver from ischaemia/reperfusion injury: a 2015 update.
- Authors
Gracia-Sancho, Jordi; Casillas-Ramírez, Araní; Peralta, Carmen
- Abstract
Ischaemia/reperfusion injury is an important cause of liver damage during surgical procedures such as hepatic resection and liver transplantation, and represents the main cause of graft dysfunction post-transplantation. Molecular processes occurring during hepatic ischaemia/reperfusion are diverse, and continuously include new and complex mechanisms. The present review aims to summarize the newest concepts and hypotheses regarding the pathophysiology of liver ischaemia/reperfusion, making clear distinction between situations of cold and warm ischaemia. Moreover, the most updated therapeutic strategies including pharmacological, genetic and surgical interventions, as well as some of the scientific controversies in the field are described.
- Subjects
ISCHEMIA; LIVER injury prevention; REPERFUSION injury; TRANSPLANTATION of organs, tissues, etc.; PATHOLOGICAL physiology; LIVER cells
- Publication
Clinical Science, 2015, Vol 129, Issue 4, p345
- ISSN
0143-5221
- Publication type
Article
- DOI
10.1042/CS20150223