We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The chemical toolbox for monitoring protein fatty acylation and prenylation.
- Authors
Hannoush, Rami N.; JingLucy Sun
- Abstract
Lipid modification of cellular proteins plays diverse roles in the regulation of such proteins' trafficking, signaling and behavior. Owing to a lack of robust detection technologies, the mechanisms by which lipids regulate proteins are poorly understood. Recently, various groups have developed innovative chemical probes in conjunction with bio-orthogonal chemistry for the detection of lipid-modified proteins in vitro and in vivo. These new methods enable further understanding of the mechanisms of protein lipidation and its function in physiology and disease. Here we present a comprehensive summary of these detection probes for monitoring fatty acylation and prenylation, and we provide a perspective on their current and future applications.
- Subjects
ACYLATION; PROTEINS; LIPIDS; CHEMICAL reactions; FUNCTIONAL groups; PHYSIOLOGICAL research
- Publication
Nature Chemical Biology, 2010, Vol 6, Issue 7, p498
- ISSN
1552-4450
- Publication type
Article
- DOI
10.1038/nchembio.388