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- Title
Enantioselective Total Synthesis of (+)-Lyngbyabellin M.
- Authors
Pirovani, Rodrigo V.; Brito, Gilmar A.; Barcelos, Rosimeire C.; Pilli, Ronaldo A.
- Abstract
Lyngbyabellin M is a non-ribosomal peptide synthetase/polyketide synthase derived metabolite isolated from the cyanobacterium M. bouillonii displaying thiazole rings and a distinct chlorinated octanoic acid chain. Its absolute configuration was proposed based on the comparison of its spectroscopic data with those of other representatives of this family of marine natural products, as well as degradation and derivatization studies. Here the first total synthesis of (+)-lyngbyabellin M is described based on the coupling of three key intermediates: two chiral thiazole moieties and an anti hydroxycarboxylic acid prepared stereoselectively via a boron enolate mediated aldol reaction directed by Masamune's chiral auxiliary.
- Subjects
PEPTIDE synthesis; CYANOBACTERIA; MARINE metabolites; OCTANOIC acid; CARBOXYLIC acids
- Publication
Marine Drugs, 2015, Vol 13, Issue 6, p3309
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md13063309