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- Title
Upregulation of oxidative stress by triphenyl phosphate (TPhP) exposure causes antioxidant insult and apoptotic process in Epithelioma papulosum cyprini (EPC) cells.
- Authors
Xiong, Ning-Xia; Fang, Zi-Xuan; Kuang, Xu-Ying; Wang, Fei; Ou, Jie; Luo, Sheng-Wei
- Abstract
Triphenyl phosphate (TPhP) is the predominant compound of organophosphate flame retardants (OPFRs), which can elicit a toxicological effect on physiological response and tissue development of fish. In this study, we investigated the effect of TPhP exposure on cell viability, antioxidant capacities, and apoptosis in EPC cells. Current study revealed that TPhP exposure could decrease cell viability and promote intracellular oxidative stress in EPC cells. In addition, high-dose TPhP exposure could facilitate antioxidant insults and cause mitochondrial collapse in a dose-dependent manner, along with increased gene expressions involved in apoptosis and unfolded protein response (UPR). These results indicated that reactive oxygen species (ROS)-induced cytotoxic stress and cell death were involved in antioxidant insults and apoptotic activation in TPhP-exposed fish cells.
- Subjects
OXIDATIVE stress; UNFOLDED protein response; FIREPROOFING agents; REACTIVE oxygen species; OXIDANT status
- Publication
Environmental Science & Pollution Research, 2023, Vol 30, Issue 56, p119217
- ISSN
0944-1344
- Publication type
Article
- DOI
10.1007/s11356-023-30697-0