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- Title
Modern Rhesus (Rh) typing in transfusion and pregnancy.
- Authors
Flegel, Willy Albert
- Abstract
Patients who are Rh negative, if transfused with Rh-positive blood, can become immunized for anti-D immunoglobulin (Ig).[1] These patients are at risk of severe transfusion reactions, and if they become pregnant, the fetus is at risk of severe anemia. A small number (0.5%) of patients have a serologic "weak D" phenotype, and when these patients need a transfusion, providers are left wondering if Rh-negative red blood cells and RhIg prophylaxis are needed. Molecular typing of weak D improves patient safety without increasing costs Although the technology for molecular typing has been established for 2 decades, only the serologic test is routinely applied.
- Subjects
EAST Asians; ERYTHROCYTES; PREGNANCY; BLOOD transfusion equipment; BLOOD grouping &; crossmatching; BLOOD transfusion
- Publication
Canadian Medical Association Journal (CMAJ), 2021, Vol 193, Issue 4, pE124
- Publication type
journal article
- DOI
10.1503/cmaj.201212