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- Title
A Retrospective Study on Blood Urea Nitrogen to Albumin Ratio in Patients with Sepsis.
- Authors
Chandrashekhar, Manoj; Kodandarama, Vishwas; Nataraj, Rajashree Ampar; Parashuram
- Abstract
BACKGROUND Sepsis is a severe, life-threatening condition characterized by systemic inflammation and multiorgan dysfunction. Identifying reliable biomarkers for early diagnosis and prognosis is crucial for improving patient outcomes. The Blood Urea Nitrogen to Albumin Ratio (BUN/Alb) has emerged as a potential indicator of sepsis severity. This study aims to evaluate the BUN/Alb ratio's utility in predicting outcomes in septic patients in Bengaluru, India. METHODS We conducted a retrospective study involving 200 sepsis patients admitted to a tertiary care hospital in Bengaluru between January 2023 and December 2023. Data were collected from electronic medical records, including BUN, albumin levels, and clinical outcomes. Statistical analyses were performed to assess the correlation between BUN/Alb ratios and patient outcomes, including mortality and length of hospital stay. RESULTS The average BUN/Alb ratio in the study population was found to be significantly higher in patients with severe sepsis compared to those with mild to moderate sepsis. A higher BUN/Alb ratio was associated with increased mortality and longer hospital stays. The ratio demonstrated predictive value for adverse outcomes, with an area under the ROC curve of 0.9. CONCLUSION The BUN/Alb ratio is a promising biomarker for assessing the severity of sepsis and predicting patient outcomes. This study supports its utility in clinical practice, especially in resource-limited settings where sophisticated diagnostic tools may not be available. Further prospective studies are recommended to validate these findings and explore the ratio's potential for guiding treatment decisions.
- Subjects
BLOOD urea nitrogen; RESOURCE-limited settings; ELECTRONIC health records; PROGNOSIS; LENGTH of stay in hospitals
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2024, Vol 15, Issue 8, p1352
- ISSN
0975-3583
- Publication type
Article