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- Title
The Effect of Adjuvant Therapies for Recurrence in Stage I Breast Cancer Patients: A Single Centre Experience.
- Authors
DOĞAN, İzzet; KHANMAMMADOV, Nijat; AYDIN, Esra; PAKSOY, Nail; FERHATOĞLU, Ferhat; AK, Naziye; EMIROĞLU, Selman; İBIŞ, Kamuran; ÖNDER, Semen; TÜKENMEZ, Mustafa; KARANLIK, Hasan; CABIOĞLU, Neslihan; KÜÇÜCÜK, Seden; MÜSLÜMANOĞLU, Mahmut; ÖZMEN, Vahit; SAIP, Pınar; İĞCI, Abdullah; AYDINER, Adnan
- Abstract
OBJECTIVE Breast cancer is the most diagnosed cancer in females. Cancer screening programs increase the detection of early-stage breast cancer. This study aimed to assess the long-term outcomes and the effect of adjuvant therapies for recurrence in stage I breast cancer patients. METHODS We recorded clinicopathological and treatment features of the stage I breast cancer patients and evaluated long-term outcomes retrospectively. Kaplan-Meier analysis and Cox regression analysis were used for recurrence and overall survival. RESULTS 308 patients with stage I breast cancer were involved in the study. The average age was 52 (range 21-81). The median follow-up was 99 (12-380) months. Forty-three (14%) patients were aged over 65, and 162 (52.7%) patients were postmenopausal. ER, PR, and HER2 receptor positivity were 78.9%, 60.8%, and 14.3%, respectively. Lumpectomy plus adjuvant radiotherapy was performed in 82.1% of the patients, and mastectomy in 10.7% of the patients for primary treatment. The patients received adjuvant chemotherapy (42.5%) and adjuvant hormonal therapy (79.9%). Recurrence (local-47.8%, metastatic-52.2%) occurred in 23 (7.5%) patients. In multivariate Cox regression analysis, we found that primary treatment (lumpectomy + adjuvant RT or mastectomy) (p=0.614), surgical margin status (p=0.495), adjuvant chemotherapy (p=0.259), and adjuvant hormonal therapy (p=0.289) were not statistically significant factors for recurrence. However, aged over 65 years (p=0.002) was statistically significant. CONCLUSION In this study, we showed long-term outcomes in stage I breast cancer patients. It was shown that the primary treatment type (lumpectomy + adjuvant RT or mastectomy) was not different in terms of recurrence. In addition, it was determined that adjuvant chemotherapy did not provide benefit for recurrence in stage I breast cancer patients in our results. For this reason, in patients with stage I cancer, more care should be taken in the decision of adjuvant therapy.
- Subjects
TURKEY; BREAST cancer prognosis; BREAST tumor treatment; RISK assessment; CANCER relapse; RADIOTHERAPY; HORMONE receptor positive breast cancer; ANTINEOPLASTIC agents; BREAST tumors; TREATMENT effectiveness; RETROSPECTIVE studies; POSTMENOPAUSE; DESCRIPTIVE statistics; AGE distribution; MULTIVARIATE analysis; ADJUVANT chemotherapy; LONGITUDINAL method; KAPLAN-Meier estimator; METASTASIS; HORMONE therapy; MASTECTOMY; PROPORTIONAL hazards models; OVERALL survival; LUMPECTOMY; EVALUATION; DISEASE risk factors
- Publication
Turkish Journal of Oncology / Türk Onkoloji Dergisi, 2024, Vol 39, Issue 3, p257
- ISSN
1300-7467
- Publication type
Article
- DOI
10.5505/tjo.2024.4209