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- Title
Marrow talaromycosis as the initial presentation in a case of Burkitt lymphoma.
- Authors
HASBULLAH, Nurull Eddayu; RAJA SABUDIN, Raja Zahratul Azma; ASRI, Alia Suzana; YUSOF, Nurasyikin; Chooi Fun LEONG; MOHAMMED, Fazarina; Chuan Hun DING; TUMIAN, Nor Rafeah
- Abstract
Talaromyces marneffei is a thermally dimorphic fungus which causes opportunistic infections in immunocompromised individuals. The diagnosis of T. marneffei infection rests on the microscopic demonstration of the fungus in the tissues and/or isolation of the fungus from clinical specimens. In this report, we discuss a case involving a 23-year-old man who presented with a history of intermittent fever, cough and constitutional symptoms. Clinically, the patient exhibited pallor, jaundice, generalized seborrhoeic dermatitis, hepatomegaly, and small palpable cervical lymph nodes. A computed tomography (CT) scan of the abdomen showed homogenous hypodense lesions in both liver lobes. HIV screening result was reactive. Microscopic examination of the bone marrow aspirate smear and trephine biopsy identified fungal bodies, and culture of the marrow aspirate confirmed the presence of T. marneffei. Notably, the liver biopsy revealed Burkitt lymphoma alongside fungal bodies. He was treated with intravenous Amphotericin B but ultimately succumbed to the illness due to severe metabolic acidosis and multiorgan failure. This case underscores the importance of presumptive diagnosis through morphological or histological examination of bone marrow samples, as microbiologic culture methods can be time-consuming. Timely diagnosis and aggressive treatment are critical in managing patients with T. marneffei infection.
- Subjects
BONE marrow examination; OPPORTUNISTIC infections; MALARIA; MULTIPLE organ failure; AMPHOTERICIN B
- Publication
Malaysian Journal of Pathology, 2024, Vol 46, Issue 2, p325
- ISSN
0126-8635
- Publication type
Case Study