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- Title
The Regulation of MicroRNA-21 by Interleukin-6 and Its Role in the Development of Fibrosis in Endometriotic Lesions.
- Authors
Ochoa Bernal, Maria Ariadna; Song, Yong; Joshi, Niraj; Burns, Gregory W.; Paul, Emmanuel N.; Vegter, Erin; Hrbek, Samantha; Sempere, Lorenzo F.; Fazleabas, Asgerally T.
- Abstract
Endometriosis is one of the most common causes of chronic pelvic pain and infertility that affects 10% of women of reproductive age. It is currently defined as the presence of endometrial epithelial and stromal cells at ectopic sites; however, advances in endometriosis research have some authors believing that endometriosis should be re-defined as "a fibrotic condition in which endometrial stroma and epithelium can be identified". microRNAs (miRNAs) are regulatory molecules that potentially play a role in endometriotic lesion development. There is evidence that suggests that miRNAs, including microRNA-21 (miR-21), participate in fibrotic processes in different organs, including the heart, kidney, liver and lungs. The objective of this study was to understand the role of miR-21 and the mechanisms that can contribute to the development of fibrosis by determining how IL-6 regulates miR-21 expression and how this miRNA regulates the transforming growth factor beta (TGF-β) signaling pathway to promote fibrosis. We investigated the expression of miR-21 in the baboon and mouse model of endometriosis and its correlation with fibrosis. We demonstrated that inflammation and fibrosis are present at a very early stage of endometriosis and that the inflammatory environment in the peritoneal cavity, which includes interleukin 6 (IL-6), can regulate the expression of miR-21 in vitro and in vivo.
- Subjects
TRANSFORMING growth factors-beta; GENE expression; CHILDBEARING age; PERITONEUM; EPITHELIAL cells
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 16, p8994
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25168994