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- Title
Serum Deprivation-Induced Upregulation of Voltage-Dependent Sodium Channels in Adrenal Chromaffin Cells.
- Authors
YANAGITA, TOSHIHIKO; KOBAYASHI, HIDEYUKI; YOKOO, HIROKI; SAITOH, TOMOKAZU; MINAMI, SHIN-ICHI; SHIRAISHI, SEIJI; UEZONO, YASUHITO; WADA, AKIHIKO
- Abstract
A bstract: In the present study, we investigated whether activation of the MAPK family could regulate the cell surface expression of Na channels in cultured bovine adrenal chromaffin cells. The results suggest that constitutively activated ERK (but not p38 or JNK), by various extracellular stimuli, downmodulates the density of cell surface Na channels, which was mediated via the destabilization of Na channel α-subunit mRNA.
- Publication
Annals of the New York Academy of Sciences, 2002, Vol 971, Issue 1, p153
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2002.tb04453.x