We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Topical treatment in vitiligo and the potential uses of new drug delivery systems.
- Authors
Garg, Bhawna Jain; Saraswat, Abir; Bhatia, Amit; Katare, Om Prakash
- Abstract
Vitiligo is a psychologically devastating condition. Topical therapy is employed as first-line treatment in localized vitiligo. Currently, several topical agents are available in many forms viz. methoxsalen (solution and cream), trioxsalen (solution), corticosteroids (gel, cream, ointment and solution) and calcineurin inhibitors (ointment and cream). Although topical therapy has an important position in vitiligo treatment, side-effects or poor efficacy affect their utility and patient compliance. Novel drug delivery strategies can play a pivotal role in improving the topical delivery of various drugs by enhancing their epidermal localization with a concomitant reduction in their side-effects and improving their effectiveness. The current review emphasizes the potential of various phospholipid based carriers viz. liposomes, transferosomes, ethosomes, lipid emulsions, solid lipid nanoparticles and organogels in optimizing and enhancing the topical delivery of anti-vitiligo agents, whilst reducing the side effects of drugs commonly used in its topical treatment.
- Subjects
VITILIGO; ANTISEPTICS; ADRENOCORTICAL hormones; DRUG delivery systems; DRUG side effects; DRUG efficacy; PHOSPHOLIPIDS; THERAPEUTICS
- Publication
Indian Journal of Dermatology, Venereology & Leprology, 2010, Vol 76, Issue 3, p231
- ISSN
0378-6323
- Publication type
Article
- DOI
10.4103/0378-6323.62961