We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Protective Effects of Polysaccharide of Atractylodes Macrocephala Koidz against Porcine Aortic Valve Endothelial Cells Damage Induced by di (2-ethylhexyl) Phthalate.
- Authors
Liu, Yunfeng; Sun, Zongyi; Zhou, Xiaoling; Wang, Haibin; Yu, Miaomiao; Li, Dejun
- Abstract
The activation, injury, and dysfunction of endothelial cells are considered to be the initial key events in the development of atherosclerosis. Di (2-ethylhexyl) phthalate (DEHP), a prevalent organic pollutant, can cause damage to multiple organs. Polysaccharide of Atractylodes macrocephala Koidz (PAMK) is a bioactive compound extracted from A. macrocephala Koidz with various biological activities. This study investigates the protective effects of PAMK on porcine aortic valve endothelial cells (PAVEC) damaged by DEHP. PAVECs treated with DEHP alone or with PAMK showed reduced cell apoptosis and death in PAMK-pretreated cells. PAMK up-regulated Bcl-2 expression and down-regulated Bax protein, suppressing apoptosis. Flow cytometry analysis demonstrated that PAMK protected PAVECs from DEHP-induced damage. These findings suggest that PAMK inhibits cell apoptosis and protects against DEHP damage in endothelial cells.
- Subjects
AORTIC valve; ENDOTHELIAL cells; BAX protein; POLYSACCHARIDES; CELL death
- Publication
Cell Biochemistry & Biophysics, 2024, Vol 82, Issue 2, p1409
- ISSN
1085-9195
- Publication type
Article
- DOI
10.1007/s12013-024-01295-9