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- Title
Dioscorea deltoidea Leaf Extract (DDLE) Attenuates Cisplatin-Induced Ovarian Injury via Regulation of Oxidative Stress.
- Authors
Wu, JiaYing; Xiong, Ying; Xu, Bin; Huang, ZhenMin; Cheng, XiaoFang
- Abstract
The present study investigated Dioscorea deltoidea leaf extract (DDLE) for treatment of cisplatin-induced ovarian injury in rat model. DDLE treatment of the cisplatin-induced ovarian injury rats suppressed Follicle-stimulating hormone (FSH) release and promoted the estrogen E2 level in serum samples. Development of follicles was increased while as damage to ovarian cortex on day 14, 28, and 42 was inhibited in cisplatin-induced ovarian injury rats on treatment with DDLE. In cisplatin-induced ovarian injury rat model oxidative stress showed a significant increase because of reduction in the level of antioxidant enzyme activity. However, DDLE treatment led to a prominent increase in activity of antioxidant enzyme compared to the control group. Moreover, DDLE treatment regulated the expression of Nuclear factor erythroid 2-related factor 2 protein in cisplatin-induced ovarian injury rats. In conclusion, DDLE treatment prevents cisplatin-induced ovarian injury through inhibition of malondialdehyde (MDA) level and upregulation of superoxide dismutase (SOD) and catalase (CAT) activity.
- Subjects
CISPLATIN; YAMS; OXIDATIVE stress; ANIMAL disease models; SUPEROXIDE dismutase; WOUNDS &; injuries
- Publication
Doklady Biochemistry & Biophysics, 2021, Vol 499, Issue 1, p282
- ISSN
1607-6729
- Publication type
Article
- DOI
10.1134/S1607672921040086