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- Title
Development of a Route to the Most Active Nafronyl Stereoisomer by Coupling Asymmetric Synthesis and Chiral Chromatography Separation.
- Authors
Olbrycht, Maksymilian; Bajek-Bil, Agata; Balawejder, Maciej; Poplewska, Izabela; Piątkowski, Wojciech; Antos, Dorota
- Abstract
Nafronyl is a pharmaceutically active compound used as a drug ingredient. It occurs in form of four stereoisomers, with however different biological activities. A procedure for preparation of the most active stereoisomer of nafronyl was developed. The stereoselective synthesis was used to produce a pair of diastereoisomers, which included the target stereoisomer. The mixture obtained was then separated by chiral chromatography in a batch mode. The efficiency of the separation in a continuous mode in a classical simulated moving‐bed system was assessed. To improve the yield of the whole operation, the less active diastereoisomer was subjected to diastereoisomeric conversion, which delivered back the pair of diastereoisomers that could be recycled to the chromatographic separation.
- Subjects
ASYMMETRIC synthesis; CHROMATOGRAPHIC analysis; DRUG utilization; DOSAGE forms of drugs; DIASTEREOISOMERS
- Publication
Chemical Engineering & Technology, 2021, Vol 44, Issue 9, p1686
- ISSN
0930-7516
- Publication type
Article
- DOI
10.1002/ceat.202100074