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- Title
A Nanobody‐Conjugated DNA Nanoplatform for Targeted Platinum‐Drug Delivery.
- Authors
Wu, Tiantian; Liu, Jianbing; Liu, Manman; Liu, Shaoli; Zhao, Shuai; Tian, Run; Wei, Dengshuai; Liu, Yangzhong; Zhao, Yao; Xiao, Haihua; Ding, Baoquan
- Abstract
The targeted delivery of chemotherapeutic drugs is a major challenge in the clinical treatment of cancer. Herein, we constructed a multifunctional DNA nanoplatform as a versatile carrier of the highly potent platinum‐based DNA intercalator, 56MESS. In our rational design, 56MESS was efficiently loaded into the double‐bundle DNA tetrahedron through intercalation with the DNA duplex. With the integration of a nanobody that both targets and blocks epidermal growth factor receptor (EGFR), the DNA nanocarriers exhibit excellent selectivity for cells with elevated EGFR expression (a common biomarker related to tumor formation) and combined tumor therapy without obvious systemic toxicity. This DNA‐based platinum‐drug delivery system provides a promising strategy for the treatment of tumors.
- Subjects
EPIDERMAL growth factor receptors; DNA; TARGETED drug delivery
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 40, p14362
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201909345