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- Title
Sulfonamidation of Aryl and Heteroaryl Halides through Photosensitized Nickel Catalysis.
- Authors
Kim, Taehoon; McCarver, Stefan J.; Lee, Chulbom; MacMillan, David W. C.
- Abstract
Abstract: Herein we report a highly efficient method for nickel‐catalyzed C−N bond formation between sulfonamides and aryl electrophiles. This technology provides generic access to a broad range of N‐aryl and N‐heteroaryl sulfonamide motifs, which are widely represented in drug discovery. Initial mechanistic studies suggest an energy‐transfer mechanism wherein C−N bond reductive elimination occurs from a triplet excited NiII complex. Late‐stage sulfonamidation in the synthesis of a pharmacologically relevant structure is also demonstrated.
- Subjects
NICKEL catalysts; CHEMICAL bonds; SULFONAMIDES; ELECTROPHILES; AMIDATION
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 13, p3546
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201800699