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- Title
Nickel(0)-Catalyzed Hydroarylation of Styrenes and 1,3-Dienes with Organoboron Compounds.
- Authors
Xiao, Li‐Jun; Cheng, Lei; Feng, Wei‐Min; Li, Mao‐Lin; Xie, Jian‐Hua; Zhou, Qi‐Lin
- Abstract
A Ni-catalyzed hydroarylation of styrenes and 1,3-dienes with organoboron compounds has been developed. The reaction offers a highly selective approach to diarylalkanes and allylarenes under redox-neutral conditions. In this hydroarylation reaction, a new strategy that uses the proton of methanol to generate the active catalyst species Ni−H was developed. The Ni-catalyzed hydroarylation, combined with a Ir-catalyzed C−H borylation, affords a very efficient and straightforward access to a retinoic acid receptor agonist.
- Subjects
NICKEL catalysts; ARYLATION; STYRENE; DIOLEFINS; ORGANOBORON compounds
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 2, p470
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201710735