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- Title
Enantioselective Aza-Ene-type Reactions of Enamides with Gold Carbenes Generated from α-Diazoesters.
- Authors
Zhao, Feng; Li, Nan; Zhang, Tao; Han, Zhi ‐ Yong; Luo, Shi ‐ Wei; Gong, Liu ‐ Zhu
- Abstract
Carbophilic gold carbenes generated from the decomposition of α-diazoesters show high reactivity towards enamides, leading to an unprecedented aza-ene-type reaction. The presence of 0.1 mol % of a chiral Brønsted acid co-catalyst is sufficient to give synthetically relevant γ-keto esters in excellent yields and selectivities (up to 99 % yield, 97 % ee).
- Subjects
GOLD carbenes; AZA compounds; CATALYTIC activity; ENANTIOSELECTIVE catalysis; CHEMICAL reactions
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 12, p3295
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201612208