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- Title
<sup>19</sup>F NMR Spectroscopy as a Highly Sensitive Method for the Direct Monitoring of Confined Crystallization within Nanoporous Materials.
- Authors
Nartowski, Karol P.; Malhotra, Diksha; Hawarden, Lucy E.; Sibik, Juraj; Iuga, Dinu; Zeitler, J. Axel; Fábián, László; Khimyak, Yaroslav Z.
- Abstract
The introduction of fluorine into the structure of pharmaceuticals has been an effective strategy for tuning their pharmacodynamic properties, with more than 40 new drugs entering the market in the last 15 years. In this context, 19F NMR spectroscopy can be viewed as a useful method for investigating the host-guest chemistry of pharmaceuticals in nanosized drug-delivery systems. Although the interest in confined crystallization, nanosized devices, and porous catalysts is gradually increasing, understanding of the complex phase behavior of organic molecules confined within nanochambers or nanoreactors is still lacking. Using 19F magic-angle-spinning NMR spectroscopy, we obtained detailed mechanistic insight into the crystallization of flufenamic acid (FFA) in a confined environment of mesoporous silica materials with different pore diameters (3.2-29 nm), providing direct experimental evidence for the formation of a molecular-liquid-like layer besides crystalline confined FFA form I.
- Subjects
NUCLEAR magnetic resonance spectroscopy; CRYSTALLIZATION; NANOPOROUS materials; PHARMACODYNAMICS; DRUG delivery systems
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 31, p9050
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201602936