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- Title
Direct Catalytic Asymmetric Doubly Vinylogous Michael Addition of α,β-Unsaturated γ-Butyrolactams to Dienones.
- Authors
Gu, Xiaodong; Guo, Tingting; Dai, Yuanyuan; Franchino, Allegra; Fei, Jie; Zou, Chuncheng; Dixon, Darren J.; Ye, Jinxing
- Abstract
An asymmetric doubly vinylogous Michael addition (DVMA) of α,β-unsaturated γ-butyrolactams to sterically congested β-substituted cyclic dienones with high site-, diastereo-, and enantioselectivity has been achieved. An unprecedented DVMA/vinylogous Michael addition/isomerization cascade reaction affords chiral fused tricyclic γ-lactams with four newly formed stereocenters.
- Subjects
CATALYTIC activity; ASYMMETRY (Chemistry); MICHAEL reaction; UNSATURATED compounds; LACTAMS
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 35, p10387
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201504276