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- Title
Enzymatic synthesis of an acylated phloroglucinol derivative with phloroglucinol and vinyl octanoate in acetonitrile.
- Authors
Park, Soo Je; Sin, Yeong Min; Lee, Sang Ok; Lee, Tae Ho
- Abstract
Monooctanoyl phloroglucinol with anti-microbial activities was synthesized from phloroglucinol (50 mM) and vinyl octanoate (150 mM) with agitation at 40 °C using 10 mg lipase AK (Pseudomonas fluorescens) in acetonitrile (1 ml, aw=0.07). The yield was approximately 70% as conversion rate of phloroglucinol over 3 days. The product, at 205 μg ml-1, was bacteriocidal against Escherichia coli and Staphylococcus epidermidis.
- Subjects
ENZYMES; CHEMICAL synthesis; ACETONITRILE; PSEUDOMONAS fluorescens; STAPHYLOCOCCUS; LIPASES; HYDROLASES
- Publication
Biotechnology Letters, 2002, Vol 24, Issue 3, p181
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1023/A:1014192821116