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- Title
Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region.
- Authors
Miyauchi, Tomoya; Tokura, Tatsuya; Kimura, Hiroyuki; Ito, Mikiko; Umemura, Eri; Sato (Boku), Aiji; Nagashima, Wataru; Tonoike, Takashi; Yamamoto, Yasuko; Saito, Kuniaki; Kurita, Kenichi; Ozaki, Norio
- Abstract
Objective: Burning mouth syndrome (BMS) and atypical odontalgia (AO) are examples of somatic symptom disorders with predominant pain around the orofacial region. Neuroinflammation is thought to play a role in the mechanisms, but few studies have been conducted. We aimed to better understand the role of neuroinflammation in the pathophysiology and treatment of BMS/AO. Methods: Plasma levels of 28 neuroinflammation‐related molecules were determined in 44 controls and 48 BMS/AO patients both pretreatment and 12‐week post‐treatment with duloxetine. Results: Baseline plasma levels of interleukin (IL)‐1β (p < .0001), IL‐1 receptor antagonist (p < .001), IL‐6 (p < .0001), macrophage inflammatory protein‐1β (p < .0001), and platelet‐derived growth factor‐bb (.04) were significantly higher in patients than in controls. Plasma levels of granulocyte macrophage colony stimulating factor were significantly higher in patients than in controls (p < .001) and decreased with treatment (.009). Plasma levels of eotaxin, monocyte chemoattractant protein‐1, and vascular endothelial growth factor decreased significantly with treatment (p < .001,.022, and.029, respectively). Conclusions: Inflammatory mechanisms may be involved in the pathophysiology and/or treatment response of somatic symptom disorders with predominant pain around the orofacial region.
- Subjects
OROFACIAL pain; GRANULOCYTES; THERAPEUTICS; BURNING mouth syndrome; VASCULAR endothelial growth factors; DISEASES
- Publication
Human Psychopharmacology: Clinical & Experimental, 2019, Vol 34, Issue 4, pN.PAG
- ISSN
0885-6222
- Publication type
Article
- DOI
10.1002/hup.2698