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- Title
A Split-Face Comparison of Novel Microneedle Patch versus Botulinum Toxin-A and Microneedle Patch for Improvement in Undereye Skin Texture.
- Authors
Te, Polen; Meephansan, Jitlada; Sirithanabadeekul, Punyaphat; Pureesrisak, Purit; Tantisantisom, Kittipong; Thongma, Sattra; Rayanasukha, Yossawat; Adulyaritthikul, Punyanuch; Khanchaitit, Paisan
- Abstract
(1) Background: The emergence of microneedle patch technology and its development as a transdermal drug delivery platform have shown proven results in improving skin texture and appearance. This study was conducted to determine the efficacy of the microneedle patch (MNP)-only cosmesis of undereye skin texture and wrinkles against patch cosmesis with diluted botulinum toxin-A. (2) Methods: A total of 23 Thai females volunteered for this prospective clinical trial. Each participant was treated according to a split-face design, with the application of diluted botulinum toxin-A through MNP technology to the right undereye and a normal saline MNP application to the left undereye. Test areas were recorded at baseline and 2, 4, 8, 12, and 16 weeks after the initial treatment. (3) Results: Botulinum toxin-A was successfully delivered to the skin by MNP technology. After the initial treatment, these novel transdermal drug delivery patches significantly improved infraorbital hollowness at week 8 and wrinkles at week 16. In addition, the skin surface was markedly enhanced, with no adverse effects observed during the trial. (4) Conclusions: Novel MNPs are an effective and safe technology for use in the management of undereye skin aging. Combination treatment with botulinum toxin-A-impregnated devices gave a higher patient satisfaction than MNPs alone.
- Subjects
BOTULINUM A toxins; DRUG delivery systems; SKIN care; COSMETICS; SKIN aging
- Publication
Cosmetics (2079-9284), 2024, Vol 11, Issue 3, p100
- ISSN
2079-9284
- Publication type
Article
- DOI
10.3390/cosmetics11030100