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- Title
Simultaneous hypersensitivity reactions to trimethoprim-sulfamethoxazole and amoxicillin-clavulanate in a dog.
- Authors
Yunho Jeong; Yoon-Hwan Kim; Jin-Ok Ahn; Jin-Young Chung
- Abstract
Antibiotics are known to be able to cause hypersensitivity reactions through various mechanisms. We present a case of drug-induced immune thrombocytopenia (DITP) and anaphylactic shock occurring simultaneously in a dog after the administration of two classes of antibiotics, namely trimethoprim-sulfamethoxazole (TMP-SMX) and amoxicillinclavulanate (AMC). The patient recovered completely from DITP on discontinuation of TMP-SMX and the anaphylactic shock caused by AMC was treated with intensive care. DITP is a rare adverse drug reaction (ADR), and anaphylactic shock is a life-threatening ADR. This is the first case report of a dog manifesting two types of hypersensitivity reactions caused by two antibiotics.
- Subjects
DRUG side effects; ANAPHYLAXIS; ALLERGIES; IDIOPATHIC thrombocytopenic purpura; DOGS; SULFAMETHOXAZOLE
- Publication
Journal of Veterinary Science, 2023, Vol 24, Issue 6, p1
- ISSN
1229-845X
- Publication type
Article
- DOI
10.4142/jvs.23188