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- Title
Complementary and alternative medicine in reducing radiation-induced skin toxicity.
- Authors
Hu, Jennifer; Cui, Tengjiao; Rodriguez-Gil, Jorge; Allen, Glenn; Li, Jie; Takita, Cristiane; Lally, Brian
- Abstract
Radiation therapy-induced acute and late effects, particularly skin toxicities, have significant impact on cancer patients' quality of life and long-term survival. To date, no effective topical agents have been routinely used in the clinical setting to prevent skin toxicity. Using SKH-hr1 hairless mice, we investigated two complementary and alternative medicine in their effects on inflammation and ionizing radiation (IR)-induced skin toxicity: Calendula officinalis (CO) and Ching Wan Hung (CWH). They were applied immediately following each IR dosing of 10 Gy/day for 4 days. Skin toxicity and inflammatory factors were evaluated at multiple time points up to 15 days post-radiation. Serum interleukin (IL)-1α, monocyte chemotactic protein-1 (MCP1), keratinocyte-derived chemokine (KC), and granulocyte colony-stimulating factor (G-CSF) were significantly induced by radiation. Both CO and CWH significantly inhibited IR-induced MCP1 ( p < 0.01), KC ( p < 0.05), and G-CSF ( p < 0.001). IR-induced erythema and blood vessel dilation were significantly reduced by CWH ( p < 0.001) but not by CO at day 10 post-IR. Both agents inhibited IR-induced IL-1α ( p < 0.01), MCP1 ( p < 0.05), and vascular endothelial growth factor ( p < 0.05). There were continuous inhibitory effects of CWH on IR-induced skin toxicities and inflammation. In contrast, CO treatment resulted in skin reactions compared to IR alone. Our results suggest that both CO and CWH reduce IR-induced inflammation and CWH reduced IR-induced erythema. In summary, CWH showed promising effects in reducing IR-related inflammation and skin toxicities, and future proof-of-principal testing in humans will be critical in evaluating its potential application in preventing IR-induced skin toxicities.
- Subjects
SKIN diseases; MEDICAL terminology; LABORATORY mice; IONIZING radiation; PATHOLOGY
- Publication
Radiation & Environmental Biophysics, 2014, Vol 53, Issue 3, p621
- ISSN
0301-634X
- Publication type
Article
- DOI
10.1007/s00411-014-0540-y