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- Title
Risk factors associated with bacteremia in COVID-19 patients admitted to intensive care unit: a retrospective multicenter cohort study.
- Authors
Bonazzetti, Cecilia; Rinaldi, Matteo; Giacomelli, Andrea; Colombo, Riccardo; Ottolina, Davide; Rimoldi, Sara Giordana; Pagani, Cristina; Morena, Valentina; Ridolfo, Anna Lisa; Vatamanu, Oana; Giacomini, Maria Eugenia; Campoli, Caterina; Oreni, Letizia; Rizzardini, Giuliano; Viale, Pierluigi; Antinori, Spinello; Giannella, Maddalena
- Abstract
Purpose: This multicenter observational study was done to evaluate risk factors related to the development of BSI in patients admitted to ICU for COVID-19. Methods: All patients with COVID-19 admitted in two COVID-19 dedicated ICUs in two different hospital between 02–2020 and 02–2021 were recruited. Result: 537 patients were included of whom 265 (49.3%) experienced at least one BSI. Patients who developed bacteremia had a higher SOFA score [10 (8–12) vs 9 (7–10), p < 0.001], had been intubated more frequently [95.8% vs 75%, p < 0.001] and for a median longer time [16 days (9–25) vs 8 days (5–14), p < 0.001]. Patients with BSI had a median longer ICU stay [18 days (12–31.5) vs 9 days (5–15), p < 0.001] and higher mortality [54% vs 42.3%, p < 0.001] than those who did not develop it. Development of BSI resulted in a higher SOFA score [aHR 1.08 (95% CI 1.03–1.12)] and a higher Charlson score [csAHR 1.15 (95% CI 1.05–1.25)]. Conclusion: A high SOFA score and a high Charlson score resulted associated with BSI's development. Conversely, immunosuppressive therapy like steroids and tocilizumab, has no role in increasing the risk of bacteremia.
- Subjects
ITALY; BACTEREMIA; INTENSIVE care units; RESEARCH; LENGTH of stay in hospitals; COVID-19; SCIENTIFIC observation; CONFIDENCE intervals; STEROIDS; TOCILIZUMAB; SUPERINFECTION; CROSS infection; RETROSPECTIVE studies; TREATMENT duration; RISK assessment; HOSPITAL mortality; HOSPITAL care; QUESTIONNAIRES; RESEARCH funding; DESCRIPTIVE statistics; IMMUNOSUPPRESSIVE agents; LONGITUDINAL method; DISEASE risk factors
- Publication
Infection, 2023, Vol 51, Issue 1, p129
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-022-01853-4