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- Title
The association between dietary intake and cervical intraepithelial neoplasia grade 2 or higher among women in a high-risk rural area of China.
- Authors
Feng, Chang-Yan; Lin, Margaret; Lakhaney, Divya; Sun, Hai-Kui; Dai, Xing-Bi; Zhao, Fang-Hui; Qiao, You-Lin
- Abstract
<bold>Objective: </bold>To evaluate the relationship between dietary intake and risk of cervical intraepithelial neoplasia grade 2 or higher (CIN2+) while controlling for human papillomavirus (HPV) infection.<bold>Methods: </bold>In 1999 and 2002, 11,031 women aged 35–50, were screened as part of two cross-sectional population-based cervical cancer screening studies in China. Dietary food intake information was collected by a 79-item Food Frequency Questionnaire (FFQ). 748 HPV-positive women (557 normal biopsy; 95 CIN2, 79 CIN3 and 17 cancer) with completed interviews and biopsy results were included in our data analysis. Specific dietary food groups were classified into dark-colored vegetables, light-colored vegetables, onion vegetables, legumes, nuts, eggs, and meat. Unconditional logistic regression was used to evaluate the association between dietary intake and the risk of developing CIN2+.<bold>Results: </bold>Inverse associations between CIN2+ risk and onion vegetables, legumes, nuts, and meat were observed. Comparison of the lowest and highest tertiles for consumption of onion vegetables, legumes, nuts, and meat yielded adjusted odds ratios (ORs) of 0.589 [95% confidence intervals (CI), 0.387–0.897; P for trend = 0.011], 0.591 (95% CI, 0.392–0.892; P for trend = 0.012), 0.635 (95% CI, 0.426–0.946; P for trend = 0.019), 0.624 (95% CI, 0.406–0.958; P for trend = 0.044), respectively, for CIN2+ risk among 748 HPV-positive women. No associations were found between CIN2+ risk and dark-colored vegetables, light-colored vegetables or eggs.<bold>Conclusions: </bold>Dietary intake of onion vegetables, legumes, nuts, and meat is associated with reduced risk of CIN2+. These foods may provide a protective factor against CIN2+.
- Subjects
CHINA; CERVIX uteri diseases; DIET in disease; PAPILLOMAVIRUS diseases; AGE factors in disease; CROSS-sectional method; POPULATION health; RURAL geography; DISEASE risk factors; ASIANS; FOOD habits; HEALTH services accessibility; PAPILLOMAVIRUSES; QUESTIONNAIRES; RURAL population; TUMOR classification; UTERINE tumors; CERVICAL intraepithelial neoplasia; ODDS ratio
- Publication
Archives of Gynecology & Obstetrics, 2011, Vol 284, Issue 4, p973
- ISSN
0932-0067
- Publication type
journal article
- DOI
10.1007/s00404-010-1743-3