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- Title
Highly elevated serum CA-125 levels in patients with non-malignant gynecological diseases.
- Authors
He, Rong-Huan; Yao, Wei-Miao; Wu, Li-Yan; Mao, Yu-Yan
- Abstract
Purposes: To identify patients with highly elevated serum CA-125 levels and analyze their clinical characteristics. Methods: Patients with non-malignant gynecologic disease (NMGDs, n = 41), in whom serum CA-125 levels were over 1,000 IU/ml were retrospectively enrolled in the study. Seventy-one patients with epithelial ovarian cancer (EOC), in whom, serum CA-125 levels were over 1,000 IU/ml were included as the comparison group. Clinical parameters were compared between the two groups. Results: In NMGDs group, 43.90% of the patients had endometriosis. The median of serum CA-125 level in NMGDs was much lower than that of EOC subjects ( P < 0.001). Compared to EOC group, the patients in NMGDs group were much younger ( P < 0.001) and had fewer histories of pelvic masses ( P < 0.001) but had more clinical complaints such as acute abdominal symptoms ( P < 0.001) and/or abnormal vaginal bleeding ( P = 0.022). Clinical progresses of these two groups were correlated with changes of serum CA-125 levels by follow-up for up to 386 days. Conclusions: High levels of serum CA-125 were found not only in the EOC, but also in some NMGDs, especially in the reproductive patients with complaints of acute abdomen symptoms or abnormal vaginal bleeding.
- Subjects
FEMALE reproductive organ diseases; OVARIAN cancer; TUMOR markers; ENDOMETRIOSIS; BLOOD testing; TUMOR antigens; RETROSPECTIVE studies; GYNECOLOGY
- Publication
Archives of Gynecology & Obstetrics, 2011, Vol 283, p107
- ISSN
0932-0067
- Publication type
Article
- DOI
10.1007/s00404-010-1717-5