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- Title
Association between urinary C-megalin levels and progressive kidney dysfunction: a cohort study based on the diabetes distress and care registry at Tenri (DDCRT 24).
- Authors
Niihata, Kakuya; Nishiwaki, Hiroki; Kinoshita, Maki; Kurosawa, Kentaro; Sakuramachi, Yui; Matsunaga, Satoshi; Okamura, Shintaro; Tsujii, Satoru; Hayashino, Yasuaki; Kurita, Noriaki; Diabetes Distress and Care Registry at Tenri Study Group; Ishii, Hitoshi; Kuwata, Hirohito; Fujimura, Maki; Takano, Kiyoko; Kitatani, Masako; Kitatani, Mako; Kondo, Yaeko; Fujita, Naotaka; Ueda, Rei
- Abstract
Aims: The aim of this cohort study was to evaluate the association between urinary levels of C-megalin, a full-length form of megalin, and kidney dysfunction progression and its dependence on the urinary albumin-creatinine ratio (UACR) in individuals with diabetes. Methods: We enrolled 1,547 individuals with diabetes who visited the ambulatory clinic at Tenri Hospital, a regional tertiary-care hospital in Tenri City, Nara Prefecture, Japan, with an estimated glomerular filtration (eGFR) of ≥ 30 mL/min/1.73 m2. The hazard ratio (HR) and 95% confidence interval (CI) were estimated using Cox proportional hazard models to examine the association between urinary C-megalin levels and eGFR decline by ≥ 40% from baseline. Results: Urinary C-megalin level was not associated with ≥ 40% eGFR decline in an age-, sex-, eGFR-, systolic blood pressure-, hemoglobin-, and UACR-adjusted model in the 1,547 patients enrolled in the study. However, urinary C-megalin levels were associated with a ≥ 40% decline in eGFR when accounting for the relationship between urinary C-megalin levels and UACR in the model. This association was UACR-dependent. Conclusions: High urinary C-megalin levels were associated with progressive kidney dysfunction in individuals with diabetes, and this association was attenuated by high UACRs.
- Subjects
JAPAN; PROPORTIONAL hazards models; SYSTOLIC blood pressure; KIDNEYS; COHORT analysis; DIABETES
- Publication
Acta Diabetologica, 2023, Vol 60, Issue 12, p1643
- ISSN
0940-5429
- Publication type
Article
- DOI
10.1007/s00592-023-02144-6