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- Title
Prophylaxis and Treatment of Anaerobic Infections following Caesarean Section with Tinidazole.
- Authors
Karhunen, M.; Koskela, O.; Teisala, K.; Suikkari, A.-M.; Mattila, J.
- Abstract
The purpose of this prospective, double-blind, placebo-controlled study was to clarify the effect of a single intravenous infusion of 500 mg of tinidazole on infections that followed a caesarean section. 80 consecutive caesarean-section patients and thereafter 72 women undergoing non-elective caesarean section were randomly assigned to two groups, each receiving intravenous infusions at cord clamping. In the entire sample the incidence of endometritis/wound infection in the placebo group was 27.3% (21/77) versus 10.7% (8/75) in the tinidazole group (p < 0.01). In the non-elective caesarean-section group the incidence of endometritis/wound infection was 39.6% (21/53) in the placebo group versus 14.3% (7/49) in the tinidazole group (p < 0.01). 27 positive bacterial cultures yielded a pure anaerobic growth in 59% (16/27) of cases, of which 87.5% (14/16) were treated successfully with oral tinidazole. Copyright © 1985 S. Karger AG, Basel
- Publication
Chemotherapy (0009-3157), 1985, Vol 31, Issue 3, p228
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000238341