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- Title
Relationship between elevated creatine phosphokinase and the clinical spectrum of rhabdomyolysis.
- Authors
Veenstra, J.; Smit, W. M.; Krediet, R. T.; Arisz, L.
- Abstract
The incidence, causes and complications of severe rhabdomyolysis (creatine phosphokinase (CK) ≥5000 U/l) were studied during a 7-year study period in a large university hospital population. This condition was present in 0.074% of all admitted patients. The mortality in the study group (=93) was 32% and the incidence of acute renal failure (ARF) 51%. Ischaemia was the most frequent cause, and drugs, alcohol and/or coma were the second most common cause of severe rhabdomyolysis. Patients with rhabdomyolysis due to ischaemia were older, had ARF more often, and also had the highest mortality. Hyperkalaemia (potassium ≥5.5 mmol/1) occurred in 13% of the patients, and all of them had or developed an impaired renal function. Hypocalcaemia (calcium ≤2.00 mmol/1) was found in 41%. The incidence of ARF and electrolyte disturbances was higher in patients with CK levels exceeding 15 000 U/l. Mortality was significantly higher in patients with ARF. Plasma concentrations of potassium and calcium correlated better with the severity of renal failure than with the maximal height of plasma CK.
- Publication
Nephrology Dialysis Transplantation, 1994, Vol 9, Issue 6, p637
- ISSN
0931-0509
- Publication type
Article