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- Title
Pharmacokinetics of ciprofloxacin and vancomycin in patients with acute renal failure treated by continuous haemodialysis.
- Authors
Davies, S. P.; Azadian, B. S.; Kox, W. J.; Brown, E. A.
- Abstract
To determine appropriate doses of ciprofloxacin and vancomycin for septic patients with acute renal failure (ARF) treated by continuous arteriovenous and venovenous haemodialysis, (CAVHD/CWHD), we performed pharmacokinetic studies in patients receiving these antibiotics. All patients were treated by CAVHD/CWHD using Hospal AN69S 0.43 m filters and Fresenius 1.5% peritoneal dialysis fluid at dialysate flow rates (Qd) of 1 and 2 1/h. Patients received ciprofloxacin 200 mg i.v. 12-hourly ( =6) or 8-hourly ( =5); vancomycin 1 g i.v. was administered to 10 patients approximately every 48 h to maintain therapeutic plasma levels. For ciprofloxacin, volume of distribution (Vd) was 136.5±9.81, terminal elimination half-life (t½) 6.4±0.8 h, and total body clearance (TBC) 264.3±22.9 ml/min (mean±SEM). Mean sieving coefficient (S/C) was 0.76±0.05 and filter clearances at Qd 1 and 21/h were 16.2±1.9 and 19.9± 1.1 ml/min respectively. For vancomycin, Vd was 60.7±5.11, t½ 24.7±2.6h and TBC 31.0± 4.6 ml/min. Mean S/C was 0.66±0.08 and filter clearances at Qd 1 and 21002F;h 12.1±2.0 and 16.6± 2.0 ml/min. These data suggest that patients with ARF treated by CAVHD/CWHD should be given ciprofloxacin 200 mg i.v. 8–12-hourly and vancomycin every 48 h.
- Publication
Nephrology Dialysis Transplantation, 1992, Vol 7, Issue 8, p848
- ISSN
0931-0509
- Publication type
Article