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- Title
Bactericidal effect of gentamicin peak concentration provides a rationale for administration of bolus doses.
- Authors
McLean, Allan J.; IoannidesDemos, Lisa L.; Li, Shu C.; Bastone, Elisa B.; Spicer, W. John; McLean, A J; IoannidesDemos, L L; Li, S C; Bastone, E B; Spicer, W J
- Abstract
A study was made of the influence of peak gentamicin concentration (Cmax) independent of the area under the antibiotic concentration-time curve (AUC) on the bactericidal effect of gentamicin against Escherichia coli NCTC 10418. Bacteria in the lag phase were exposed to in-vitro gentamicin concentration-time profiles which modelled complete profiles determined in vivo in patients after an intravenous bolus (1 min) or infusion (30 min) regimen. An additional in-vitro profile reflected antibiotic removal 30 min after bolus dosing. Bacterial viable cell counts and gentamicin concentrations were measured before and during antibiotic exposure. Both Cmax and AUC were shown to be factors determining antibacterial activity; however Cmax independently represented some 35% of total exposure effect. These findings indicate grounds for preferring bolus intravenous gentamicin dosing with appropriate attention to potential toxicity.
- Subjects
BIOLOGICAL models; DOSE-effect relationship in pharmacology; ESCHERICHIA coli; GENTAMICIN; INTRAVENOUS injections; MICROBIAL sensitivity tests; PHARMACODYNAMICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1993, Vol 32, Issue 2, p301
- ISSN
0305-7453
- Publication type
journal article