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- Title
Comparative therapeutic efficacy of teicoplanin and vancomycin in normal and in neutropenic mice infected with Staphylococcus haemolyticus.
- Authors
Torney, H. L.; Balistreri, F. J.; Kenny, M. T.; Cheng, W. D.
- Abstract
This study describes the evaluation of a murine bacteraemia model for assessing antibiotic efficacy in normal and neutropenic mice infected with coagulase-negative staphylococci. In one such evaluation, it was found that there was no significant (P greater than 0.05) difference in the ability of teicoplanin or vancomycin to protect normal or neutropenic CD-1 mice, lethally-infected with Staphylococcus haemolyticus. However, about a four-fold increase of either antibiotic was needed to protect the immunocompromised animals.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1991, Vol 28, Issue 2, p261
- ISSN
0305-7453
- Publication type
journal article