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- Title
Pharmacokinetics of gentamicin after iv infusion or iv bolus.
- Authors
Meunier, F.; Van der Auwera, P.; Schmitt, H.; de Maertelaer, V.; Klastersky, J.
- Abstract
A cross-over randomized comparative study was undertaken in ten healthy subjects to study the pharmacokinetics of 80 mg of gentamicin given as a bolus iv injection or as an infusion over 15 min using a commercially available 100 ml solution. Mean peak values at the end of the two modes of injection were respectively: 17.8 and 7.8 mg/1 ( ≤ 0.002, Wilcoxon ranked pairs test). Mean peak values extrapolated at = 0 for each volunteer were respectively 4.2. and 3.8 mg/l (not statistically different). Mean serum values 1 h after administration were respectively 4.2 and 3.7 mg/1 (not statistically different). Mean trough values after 8 h were: 0.45 and 0.44 mg/l. Mean elimination half-lives were 139 and 142 min ( > 0.1).
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1987, Vol 19, Issue 2, p225
- ISSN
0305-7453
- Publication type
Article