We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pharmacokinetics of cefotetan in patients with end-stage renal failure on maintenance dialysis.
- Authors
Browning, M. J.; Holt, H. A.; White, L. O.; Chapman, S. T.; Banks, R. A.; Reeves, D. S.; Yates, R. A.
- Abstract
The pharmacokinetics of a single intravenous dose of cefotetan were studied in 17 volunteer patients with end-stage renal failure, requiring intermittent haemodialysis in 12 cases or undergoing continuous ambulatory peritoneal dialysis in 5 cases. Between haemodialysis the mean plasma elimination half life was 20.4 h (S.E.M.±2.1). This decreased to 7.5 h (S.E.M.±0.6) during haemodialysis. In patients treated by continuous ambulatory peritoneal dialysis the mean plasma elimination half life was 15.5 h (S.E.M.±1.9). Small amounts of cefotetan (5–9% of the administered dose) were recovered in the peritoneal dialysates removed over the 24 hfollowing the dose.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1986, Vol 18, Issue 1, p103
- ISSN
0305-7453
- Publication type
Article