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- Title
The Puzzle of the X: Sex Differences in Autoimmune Diseases.
- Authors
Brown, Carolyn
- Abstract
A recent article published in GEN Biotechnology by researchers from Stanford University explores the role of the Xist RNA protein complex in female-biased autoimmunity. The Xist RNA protein complex is unique to females and may contribute to the development of autoimmune diseases. The X chromosome, which is present in both males and females, contains many immune-related genes that can impact autoimmunity. The study suggests that Xist-interacting proteins may play a role in the development of systemic lupus erythematosus (SLE), a disease that affects females more frequently than males. The research highlights the complex contributions of sex-chromosome biology to autoimmune disorders and provides new insights into the puzzle of sex differences in autoimmune diseases.
- Subjects
X chromosome; SEX factors in disease; MOSAICISM; GENE silencing; RNA-binding proteins; PRIMARY immunodeficiency diseases; GENE expression
- Publication
GEN Biotechnology, 2024, Vol 3, Issue 2, p69
- ISSN
2768-1572
- Publication type
Article
- DOI
10.1089/genbio.2024.29138.cbr