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- Title
High-yield production of short chain length poly(ε- l-lysine) consisting of 5–20 residues by Streptomyces aureofaciens, and its antimicrobial activity.
- Authors
Takehara, Munenori; Hibino, Atsushi; Saimura, Masayuki; Hirohara, Hideo
- Abstract
Poly(ε- l-lysine) (ε-PL) is a naturally-occurring l-lysine homopolymer having antimicrobial activity. A newly-isolated strain of Streptomyces aureofaciens produced a short chain length ε-PL consisting of 5–20 residues at the highest production level of 4.5 g l–1. This ε-PL had different spectra in terms of antimicrobial activity from the ε-PL that is now used as a food preservative. The high productivity was based on multiple metabolic pathways for l-lysine synthesis, and a great flux from l-lysine to ε-PL. The usefulness of this new ε-PL and its producing strain was discussed.
- Subjects
STREPTOMYCES aureofaciens; AMINO acids; FOOD preservatives; STREPTOMYCES; BIOTECHNOLOGY
- Publication
Biotechnology Letters, 2010, Vol 32, Issue 9, p1299
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1007/s10529-010-0294-9