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- Title
卡维地洛与美托洛尔对维持性血液透析患者的 临床疗效和心功能的影响.
- Authors
林颖; 黄冰冰; 吴亚琴
- Abstract
Objective: To investigate the effects of carvedilol and metoprolol on the clinical efficacy and cardiac function of maintenance hemodialysis patients. Methods: 162 patients with left ventricular hypertrophy receiving maintenance hemodialysis in Qianjiang Central Hospital of Chongqing City from January 2019 to February 2020 were selected. A random number table was used to divide the patients into 2 groups, with 81 cases in each group. The control and observation group were treated with metoprolol or carvedilol apart from conventional treatment, respectively. The cardiac function indices, oxidative stress response, inflammatory factors, glucose and lipid metabolism and adverse reactions of the two groups were compared. Results: After treatment, the levels of LVEDD, LVPWT, IVST and MDA in the two groups decreased significantly, but the decrease in the observation group was greater (P<0.05). Meanwhile, the SOD and GSH-Px levels of the two groups increased significantly, but the increase in the observation group was greater (P<0.05): the levels of inflammatory factor such as hs-CRP, IL-6, IL-1B and glucose & lipid metabolism indexes such as fasting blood glucose, total cholesterol, and triglyceride levels in the two groups of patients decreased significantly, but the decrease in the observation group was even greater (P<0.05). There were 5 cases (6.17%) of adverse reactions in the control group, and 6 cases (7.40%) in the observation group, of which the difference was not statistically significant (P> 0.05). Conclusion: Compared with metoprolol, carvedilol can effectively improve the heart function of patients with left ventricular hypertrophy on maintenance hemodialysis, relieve oxidative stress and inflammation, improve glucose and lipid metabolism without increasing the incidence of adverse reactions.
- Publication
Journal of South-Central Minzu University (Natural Science Edition), 2022, Vol 41, Issue 4, p425
- ISSN
1672-4321
- Publication type
Article
- DOI
10.12130/znmdzk.20220407