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- Title
Azetidin-3-ones from ( S)-α-Amino Acids and Their Reactions with Nucleophiles: Preparation of some azetidine-containing amino-alcohol and amino-acid derivatives.
- Authors
Podlech, Joachim; Seebach, Dieter
- Abstract
The reactions of azetidin-3-ones 6- 10, readily available from the amino acids L-alanine, L-phenylalanine, L-valine, L-lysine, and L-aspartic acid, via the corresponding diazo ketones, with nucleophilic reagents such as complex hydrides, Grignard compounds, an ester enolate, and a Wittig ylide give the expected products 11- 19 in good yields and mostly in high diastereoselectivities. New amino-alcohol, γ-amino- and γ-amino-β-hydroxy-carboxylic-acid derivatives of known configurations are thus available.
- Publication
Helvetica Chimica Acta, 1995, Vol 78, Issue 5, p1238
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19950780516