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- Title
Synthese und HOFMANN-Abbau des 1-(Diphenyl-hydroxymethyl)-2,2-dimethyl-6,7-dimethoxy-1,2,3,4-tetrahydroisochinolinium-Ions.
- Authors
Wiegrebe, Wolfgang; Rohrbach-Munz, Barbara; Awe, Walter; Kirk, Olaf
- Abstract
The synthesis of the N-quaternary aminoalcohol 6 is described. Analogous to the aminoalcohols 1 and 2, 6 on treatment with alkali undergoes fission of the substituent at C(1) as a carbonyl compound, with formation of a N, N-dimethyl-1,2,3,4-tetrahydroisoquinolinium ion, which is further degraded to the corresponding o-vinyl-benzylamine ( Scheme1). - As a by-product of a Bischler-Napieralski ring closure, we observed chlorination of an aromatic ring (yielding 19).
- Publication
Helvetica Chimica Acta, 1975, Vol 58, Issue 6, p1825
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19750580639