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- Title
Light localization with low-contrast targets in a patient implanted with a suprachoroidal-transretinal stimulation retinal prosthesis.
- Authors
Endo, Takao; Fujikado, Takashi; Hirota, Masakazu; Kanda, Hiroyuki; Morimoto, Takeshi; Nishida, Kohji
- Abstract
Purpose: To evaluate the improvement in targeted reaching movements toward targets of various contrasts in a patient implanted with a suprachoroidal-transretinal stimulation (STS) retinal prosthesis.Methods: An STS retinal prosthesis was implanted in the right eye of a 42-year-old man with advanced Stargardt disease (visual acuity: right eye, light perception; left eye, hand motion). In localization tests during the 1-year follow-up period, the patient attempted to touch the center of a white square target (visual angle, 10°; contrast, 96, 85, or 74%) displayed at a random position on a monitor. The distance between the touched point and the center of the target (the absolute deviation) was averaged over 20 trials with the STS system on or off.Results: With the left eye occluded, the absolute deviation was not consistently lower with the system on than off for high-contrast (96%) targets, but was consistently lower with the system on for low-contrast (74%) targets. With both eyes open, the absolute deviation was consistently lower with the system on than off for 85%-contrast targets. With the system on and 96%-contrast targets, we detected a shorter response time while covering the right eye, which was being implanted with the STS, compared to covering the left eye (2.41 ± 2.52 vs 8.45 ± 3.78 s, p < 0.01).Conclusions: Performance of a reaching movement improved in a patient with an STS retinal prosthesis implanted in an eye with residual natural vision. Patients with a retinal prosthesis may be able to improve their visual performance by using both artificial vision and their residual natural vision.Clinical trial registration: Beginning date of the trial: Feb. 20, 2014Date of registration: Jan. 4, 2014Trial registration number: UMIN000012754Registration site: UMIN Clinical Trials Registry (UMIN-CTR)<ext-link>http://www.umin.ac.jp/ctr/index.htm</ext-link>
- Subjects
PROSTHETICS; RETINAL surgery; VISUAL acuity; LEAST absolute deviations (Statistics); RETINAL proteins; CLINICAL trials
- Publication
Graefe's Archive of Clinical & Experimental Ophthalmology, 2018, Vol 256, Issue 9, p1723
- ISSN
0721-832X
- Publication type
Article
- DOI
10.1007/s00417-018-3982-0