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- Title
cDNA cloning of putative rat acetyl-CoA transporter and its expression pattern in brain.
- Authors
Bora, R.S.; Ichikawa, S.; Kanamori, A.; Hirabayashi, Y.
- Abstract
Rat acetyl-CoA transporter gene <italic>(Acatn) </italic>encodes a hydrophobic multi-transmembrane protein involved in the <italic>O</italic>-acetylation of gangliosides. <italic>O</italic>-acetylated gangliosides have been found to play important roles in the embryonic development of the nervous system. We have isolated rat <italic>Acatn</italic> cDNA by PCR cloning. The amino acid sequence of rat Acatn exhibited 92% and 96% homology with human and mouse sequences, respectively. The mRNA was expressed in brain at all developmental stages. <italic>Acatn</italic> expression was higher in embryonic and postnatal rats than in adult rats. Cellular localization of <italic>Acatn</italic> mRNA in adult rat brain was also analyzed by in situ hybridization. <italic>Acatn</italic> mRNA expression was detected in the neuronal cells of cerebellum, hippocampus, hypothalamus, cortex, olfactory bulb, and dorsal and ventral anterior olfactory nucleus in adult rat brain.
- Publication
Cytogenetic & Genome Research, 2000, Vol 89, Issue 3/4, p204
- ISSN
1424-8581
- Publication type
Article
- DOI
10.1159/000015613