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- Title
CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17–producing γδ T cell subsets.
- Authors
Ribot, Julie C; deBarros, Ana; Pang, Dick John; Neves, Joana F; Peperzak, Victor; Roberts, Scott J; Girardi, Michael; Borst, Jannie; Hayday, Adrian C; Pennington, Daniel J; Silva-Santos, Bruno
- Abstract
The production of cytokines such as interferon-γ and interleukin 17 by αβ and γδ T cells influences the outcome of immune responses. Here we show that most γδ T lymphocytes expressed the tumor necrosis factor receptor family member CD27 and secreted interferon-γ, whereas interleukin 17 production was restricted to CD27− γδ T cells. In contrast to the apparent plasticity of αβ T cells, the cytokine profiles of these distinct γδ T cell subsets were essentially stable, even during infection. These phenotypes were established during thymic development, when CD27 functions as a regulator of the differentiation of γδ T cells at least in part by inducing expression of the lymphotoxin-β receptor and genes associated with trans-conditioning and interferon-γ production. Thus, the cytokine profiles of peripheral γδ T cells are predetermined mainly by a mechanism involving CD27.
- Publication
Nature Immunology, 2009, Vol 10, Issue 4, p427
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni.1717