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- Title
Evaluation of anti-inflammatory properties of hot water extract from Coprinus comatus using HL-60 and 3T3-L1 cells.
- Authors
Tomomi Kanno; Kimiko Kazumura; Toshio Niwa; Etsuko Harada; Yoshiaki Miyake; Toshihiko Osawa
- Abstract
In this study, the amount of ergothioneine (EGT) in hot water extracts of Coprinus comatus (Coprino extracts) was studied, and the anti-inflammatory activities of the extracts were evaluated using a cell system by simultaneously monitoring superoxide anion radical generation and intracellular Ca2+ levels in neutrophil-like HL-60 cells. The protective roles of the Coprino extracts and EGT against inflammatory oxidative damage of 3T3-L1 adipocytes induced by tumor necrosis factor alpha (TNF-a) were also examined. Based on these results, it is reasonably safe to conclude that Coprino extracts have a higher anh-mflammatory activity than EGT alone.
- Subjects
HOT water; ANTI-inflammatory agents; EXTRACTS; SUPEROXIDES; ANIONS
- Publication
Japanese Journal of Food Chemistry & Safety, 2020, Vol 27, Issue 2, p53
- ISSN
1341-2094
- Publication type
Article