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- Title
if1维持基因组稳定性在肿瘤中发挥的作用 .
- Authors
陈波; 李志杰
- Abstract
Helicase is necessary for enzymes involved in nucleic acid metabolism in a variety of organisms. Pif1 is an ATP-dependent superfamily ⅠB class of helicases that work in the 5’ to 3’ direction and is found in almost all eukaryotes. Pif1 affects telomere,mitochondrial DNA replication,and Okazaki fragment maturation to varying degrees,such as through the disruption of stable nuclear protein complexes. Based on the importance of Pif1 in maintaining genomic stability,these current findings also offer new potential therapeutic directions for tumor-related diseases. This paper reviews the role of Pif1 in maintaining genomic stability in tumors.
- Subjects
NUCLEAR proteins; NUCLEIC acids; HELICASES; DNA; ENZYMES
- Publication
Journal of China Medical University, 2022, Vol 51, Issue 4, p361
- ISSN
0258-4646
- Publication type
Article
- DOI
10.12007/j.issn.0258-4646.2022.04.014