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- Title
七氟烷预处理对肺癌细胞凋亡与增殖的影响及机制分析.
- Authors
臧 婷; 晓毅; 李紫薇; 王小雨; 彭余楠
- Abstract
Objective To investigate and analysis the effects of sevoflurane preconditioning on apoptosis and proliferation of lung cancer cells. Methods The lung cancer cell line A549 were treated with different concentrations of sevoflurane. The inhibition of cell proliferation were detected by thiazolyl blue method. The apoptosis were detected by flow cytometry. The cell transfer and invasion were detected by Transwell assay. The sevoflurane were identified by immunoblotting. Results The treatment of sevoflurane resulted in significant decreased in the proliferation rate of A549 cells (P<0.05), and were significant increased in apoptosis rate (P<0.05), and there were dose-dependent (P<0.05). At the same time, the relative expression of cell transfer and invasion index, Stromal cell-derived factor 1 (SDF-1) and CXC chemokine receptor 7 (CXCR7) protein were significantly decreased (P<0.05), and there were also dose-dependent (P<0.05). Conclusion Sevoflurane preconditioning can inhibit the SDF-1/CXCR7 signaling pathway in lung cancer cells, thereby promoting apoptosis and inhibiting cell proliferation, metastasis and invasion
- Subjects
CANCER cell proliferation; CHEMOKINE receptors; APOPTOSIS; CANCER cells; INHIBITION of cellular proliferation
- Publication
Progress in Modern Biomedicine, 2020, Vol 20, Issue 8, p1416
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2020.08.004