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- Title
鹿瓜多肽注射液与补肾壮骨胶囊对膝关节骨性关节炎患者血清BALP、 BGP、TRACP-5b 及CTX-I水平的影响
- Authors
刘伟; 张翠影; 何盛江; 张铭华; 杨帆; 栾和旭
- Abstract
Objective: To study the efficacy of Lugu Peptide Injection combined with Bushenzhuanggu Capsule on the knee osteoarthritis and effect on the serum bone specific alkaline phosphatase (BALP), osteocalcin (BGP), tartrate Phosphatase isoform 5b (TRACP-5b), type I collagen C-terminal peptide (CTX-I) levels. Methods: From April 2015 to March 2016, 84 cases of patients with knee osteoarthritis were divided into the observation group and the control group. The control group was treated with lugua peptide injection, and the observation group was supplemented with Kidney Zhuanggu Capsule. The clinical efficacy, changes of serum BALP, BGP, TRACP-5b, CTX-I levels and visual analogue scale (VAS) before and after treatment were compared between the two groups. Results: After treatment, the total effective rate of observation group was significantly higher in the observation group than that of the control group [90.48% (38/42) vs 64.29% (27/42)] (P<0.05). Compared with before treatment, the serum levels of BALP and BGP were significantly higher in both groups after treatment(P<6).6)5). The serum TRACP-5b, CTX-I levels and VAS scores were significantly lower than those before treatment (P<0.05). The levels of serum BALP and BGP in the observation group were significantly higher than those in the control group (P<0.05), the serum TRACP-5b, CTX-I levels and VAS scores were significantly lower in the observation group than those in the control group (P<0.05). Conclusion: The clinical efficacy of Lugua Peptide Injection combined with Bushenzhuanggu Capsule in the treatment of knee osteoarthritis is superior to that of Lugu polypeptide injection, which can significantly increase the serum BALP and BGP levels, decrease the serum RACP-5b, CTX-I levels and improve the bone metabolism.
- Subjects
PEPTIDE drugs; KNEE disease treatment; OSTEOARTHRITIS treatment; ALKALINE phosphatase; CONTROL groups
- Publication
Progress in Modern Biomedicine, 2018, Vol 18, Issue 16, p3127
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2018.16.028